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Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.
Flynn, Ryan; Paz, Katelyn; Du, Jing; Reichenbach, Dawn K; Taylor, Patricia A; Panoskaltsis-Mortari, Angela; Vulic, Ante; Luznik, Leo; MacDonald, Kelli K P; Hill, Geoffrey R; Nyuydzefe, Melanie S; Weiss, Jonathan M; Chen, Wei; Trzeciak, Alissa; Serody, Jon S; Aguilar, Ethan G; Murphy, William J; Maillard, Ivan; Munn, David; Koreth, John; Cutler, Corey S; Antin, Joseph H; Ritz, Jerome; Waksal, Samuel D; Zanin-Zhorov, Alexandra; Blazar, Bruce R.
Affiliation
  • Flynn R; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
  • Paz K; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
  • Du J; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
  • Reichenbach DK; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
  • Taylor PA; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
  • Panoskaltsis-Mortari A; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
  • Vulic A; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, The Johns Hopkins University, Baltimore, MD;
  • Luznik L; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, The Johns Hopkins University, Baltimore, MD;
  • MacDonald KK; Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia;
  • Hill GR; Department of Immunology, Queensland Institute of Medical Research, Brisbane, Australia;
  • Nyuydzefe MS; Kadmon Research Institute, New York, NY;
  • Weiss JM; Kadmon Research Institute, New York, NY;
  • Chen W; Kadmon Research Institute, New York, NY;
  • Trzeciak A; Kadmon Research Institute, New York, NY;
  • Serody JS; Lineberger Comprehensive Cancer Center Division of Hematology/Oncology, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC;
  • Aguilar EG; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA;
  • Murphy WJ; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA;
  • Maillard I; Life Sciences Institute and Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI;
  • Munn D; Department of Pediatrics, Georgia Health Sciences University, Augusta, GA; and.
  • Koreth J; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.
  • Cutler CS; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.
  • Antin JH; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.
  • Ritz J; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.
  • Waksal SD; Kadmon Research Institute, New York, NY;
  • Zanin-Zhorov A; Kadmon Research Institute, New York, NY;
  • Blazar BR; Division of Blood and Marrow Transplantation, Masonic Cancer Center and Department of Pediatrics, University of Minnesota, Minneapolis, MN;
Blood ; 127(17): 2144-54, 2016 04 28.
Article in En | MEDLINE | ID: mdl-26983850
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase Inhibitors / STAT3 Transcription Factor / Rho-Associated Kinases / Graft vs Host Disease Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Blood Year: 2016 Type: Article
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Protein Kinase Inhibitors / STAT3 Transcription Factor / Rho-Associated Kinases / Graft vs Host Disease Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Blood Year: 2016 Type: Article