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A Multifunctional PB@mSiO2-PEG/DOX Nanoplatform for Combined Photothermal-Chemotherapy of Tumor.
Su, Yun Yan; Teng, Zhaogang; Yao, Hui; Wang, Shou Ju; Tian, Ying; Zhang, Yun Lei; Liu, Wen Fei; Tian, Wei; Zheng, Li Juan; Lu, Nan; Ni, Qian Qian; Su, Xiao Dan; Tang, Yu Xia; Sun, Jing; Liu, Ying; Wu, Jiang; Yang, Gui Fen; Lu, Guang Ming; Zhang, Long Jiang.
Affiliation
  • Su YY; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Teng Z; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Yao H; Department of Hepatopancreatobiliary Surgery, Drum Tower Hospital, Medical School of Nanjing University , Nanjing 210008, People's Republic of China.
  • Wang SJ; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Tian Y; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Zhang YL; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Liu WF; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Tian W; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Zheng LJ; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Lu N; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Ni QQ; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Su XD; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications , Nanjing 210046, People's Republic of China.
  • Tang YX; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Sun J; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Liu Y; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Wu J; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Yang GF; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Lu GM; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
  • Zhang LJ; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University , Nanjing 210002, People's Republic of China.
ACS Appl Mater Interfaces ; 8(27): 17038-46, 2016 Jul 13.
Article in En | MEDLINE | ID: mdl-27065014
ABSTRACT
In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO2-PEG nanocubes. The PB@mSiO2-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO2-PEG nanocubes, the constructured PB@mSiO2-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO2-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.
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Full text: 1 Database: MEDLINE Main subject: Nanostructures Language: En Journal: ACS Appl Mater Interfaces Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Nanostructures Language: En Journal: ACS Appl Mater Interfaces Year: 2016 Type: Article