Administration of Piceatannol Complexed with α-Cyclodextrin Improves Its Absorption in Rats.
J Agric Food Chem
; 64(18): 3557-63, 2016 May 11.
Article
in En
| MEDLINE
| ID: mdl-27078058
ABSTRACT
Piceatannol is polyphenolic antioxidant found in passion fruit (Passiflora edulis) seeds. The aim of this study was to improve the absorption of piceatannol using α-cyclodextrin (αCD). The solubility of piceatannol in neutral and acidic solutions increased in an αCD concentration-dependent manner. The maximum plasma concentration of intact piceatannol and the time-to-maximum plasma concentration of O-methylated piceatannol metabolites increased in rats administered αCD-piceatannol inclusion complexes (PICs). Administering the αCD inclusion complexes significantly increased the area under the concentration-time curve of total stilbene derivatives (0-3 h) in terms of the total amount of intact piceatannol, O-methylated piceatannol, conjugated piceatannol, and isorhapontigenin. Gastrointestinal ligation experiments demonstrated that substantially higher levels of piceatannol metabolites were present in the lower intestine (the ileum) at 1 h postintragastric αCD-PICs administration as compared to those observed following piceatannol administration only. These results suggested that αCD enhanced piceatannol movement and absorption in the small intestine.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Seeds
/
Stilbenes
/
Plant Extracts
/
Passiflora
Language:
En
Journal:
J Agric Food Chem
Year:
2016
Type:
Article
Affiliation country:
Japan