The Roles of 4ß-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells.

Peng, Chieh Yu; You, Bang Jau; Lee, Chia Lin; Wu, Yang Chang; Lin, Wen Hsin; Lu, Te Ling; Chang, Fei-Ching; Lee, Hong Zin

Peng, Chieh Yu; You, Bang Jau; Lee, Chia Lin; Wu, Yang Chang; Lin, Wen Hsin; Lu, Te Ling; Chang, Fei-Ching; Lee, Hong Zin.

Affiliation

Peng CY; * School of Pharmacy, China Medical University Hospital, Taichung, Taiwan.
You BJ; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, Taiwan.
Lee CL; Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung, Taiwan.
Wu YC; § Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
Lin WH; * School of Pharmacy, China Medical University Hospital, Taichung, Taiwan.
Lu TL; § Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
Chang FC; * School of Pharmacy, China Medical University Hospital, Taichung, Taiwan.
Lee HZ; * School of Pharmacy, China Medical University Hospital, Taichung, Taiwan.

Am J Chin Med ; 44(3): 617-36, 2016.

Article in En | MEDLINE | ID: mdl-27109152

Subject(s)

Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis/drug effects; Apoptosis/genetics; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Cell Cycle/drug effects; NF-E2-Related Factor 2/metabolism; Physalis/chemistry; Phytotherapy; Reactive Oxygen Species/metabolism; Withanolides/pharmacology; Withanolides/therapeutic use; Animals; Ataxia Telangiectasia Mutated Proteins; DNA Damage/drug effects; DNA Damage/genetics; Disease Models, Animal; Glutathione; Humans; MCF-7 Cells; Signal Transduction/genetics; Signal Transduction/physiology; Withanolides/isolation & purification

Key words

4-Hydroxywithanolide E; Antioxidative Defense Enzymes; Breast Cancer MCF-7 Cells; Human Breast Cancer MDA-MB231 Xenograft Tumor Model; Nrf2; Ras/Raf/ERK Pathway; Reactive Oxygen Species

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Breast Neoplasms / Cell Cycle / Reactive Oxygen Species / Apoptosis / Physalis / NF-E2-Related Factor 2 / Withanolides / Phytotherapy / Antineoplastic Agents, Phytogenic / Antioxidants Type of study: Prognostic_studies Language: En Journal: Am J Chin Med Year: 2016 Type: Article Affiliation country: Taiwan

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