In Vivo Inhibition of Proteasome Activity and Tumour Growth by Murraya koenigii Leaf Extract in Breast Cancer Xenografts and by Its Active Flavonoids in Breast Cancer Cells.

Noolu, Bindu; Gogulothu, Ramesh; Bhat, Mehrajuddin; Qadri, Syed S Y H; Reddy, V Sudhakar; Reddy, G Bhanuprakash; Ismail, Ayesha

Noolu, Bindu; Gogulothu, Ramesh; Bhat, Mehrajuddin; Qadri, Syed S Y H; Reddy, V Sudhakar; Reddy, G Bhanuprakash; Ismail, Ayesha.

Affiliation

Ismail A; Department of Endocrinology & Metabolism, National Institute of Nutrition, Jamai Osmania, PO, Tarnaka, Hyderabad, India- 500007. ayeshai2005@gmail.com.

Anticancer Agents Med Chem ; 16(12): 1605-1614, 2016.

Article in En | MEDLINE | ID: mdl-27198988

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Breast Neoplasms/drug therapy; Flavonoids/pharmacology; Murraya/chemistry; Plant Extracts/pharmacology; Proteasome Endopeptidase Complex/metabolism; Proteasome Inhibitors/pharmacology; Animals; Antineoplastic Agents, Phytogenic/chemistry; Antineoplastic Agents, Phytogenic/isolation & purification; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Flavonoids/chemistry; Flavonoids/isolation & purification; Humans; Mammary Neoplasms, Experimental/drug therapy; Mammary Neoplasms, Experimental/pathology; Mice; Mice, Inbred BALB C; Mice, Nude; Plant Extracts/chemistry; Plant Extracts/isolation & purification; Plant Leaves/chemistry; Proteasome Inhibitors/chemistry; Proteasome Inhibitors/isolation & purification; Structure-Activity Relationship

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Database: MEDLINE Main subject: Flavonoids / Breast Neoplasms / Plant Extracts / Murraya / Proteasome Endopeptidase Complex / Proteasome Inhibitors / Antineoplastic Agents, Phytogenic Language: En Journal: Anticancer Agents Med Chem Year: 2016 Type: Article

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