Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator-activated receptor (PPAR)-&#945;/Î³ and attenuating endoplasmic reticulum stress in rats.

Ge, Jing; Miao, Jun-Jun; Sun, Xin-Yi; Yu, Jiang-Yi

Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, improves diabetic nephropathy via activating peroxisome proliferator-activated receptor (PPAR)-α/Î³ and attenuating endoplasmic reticulum stress in rats.

Ge, Jing; Miao, Jun-Jun; Sun, Xin-Yi; Yu, Jiang-Yi.

Affiliation

Ge J; Jiangsu Province Hosipital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing Hanzhong Road, Nanjing, China.
Miao JJ; Jiangsu Province Hosipital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing Hanzhong Road, Nanjing, China.
Sun XY; Jiangsu Province Hosipital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing Hanzhong Road, Nanjing, China.
Yu JY; Jiangsu Province Hosipital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing Hanzhong Road, Nanjing, China. Electronic address: jiangyiyunjcm@sohu.com.

J Ethnopharmacol ; 189: 238-49, 2016 Aug 02.

Article in En | MEDLINE | ID: mdl-27224243

Subject(s)

Abelmoschus/chemistry; Diabetic Nephropathies/drug therapy; Drugs, Chinese Herbal/pharmacology; Endoplasmic Reticulum Stress/drug effects; Kidney/drug effects; PPAR alpha/agonists; PPAR gamma/agonists; Plant Extracts/pharmacology; Administration, Oral; Albuminuria/metabolism; Albuminuria/prevention & control; Animals; Biphenyl Compounds/pharmacology; Capsules; Diabetes Mellitus, Experimental/chemically induced; Diabetic Nephropathies/blood; Diabetic Nephropathies/etiology; Diabetic Nephropathies/pathology; Drugs, Chinese Herbal/administration & dosage; Drugs, Chinese Herbal/isolation & purification; Gene Expression Regulation; Glomerulonephritis/metabolism; Glomerulonephritis/prevention & control; HEK293 Cells; Hep G2 Cells; Humans; Irbesartan; Kidney/metabolism; Kidney/pathology; Lipids/blood; Liver/drug effects; Liver/metabolism; Male; Nephrectomy; PPAR alpha/genetics; PPAR alpha/metabolism; PPAR gamma/genetics; PPAR gamma/metabolism; Phytotherapy; Plant Extracts/administration & dosage; Plant Extracts/isolation & purification; Plants, Medicinal; Rats, Sprague-Dawley; Signal Transduction/drug effects; Streptozocin; Tetrazoles/pharmacology; Transfection

Key words

Diabetic nephropathy; Endoplasmic reticulum stress; Fenofibrate (PubChem CID: 3339); Huangkui capsule; Irbesartan (PubChem CID: 3749); PPARα/Î³; Streptozocin (PubChem CID: 29327); Thapsigargin (PubChem CID: 446378); Troglitazone (PubChem CID: 5591)

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Plantas_medicinales Main subject: Drugs, Chinese Herbal / Plant Extracts / Abelmoschus / PPAR alpha / PPAR gamma / Diabetic Nephropathies / Endoplasmic Reticulum Stress / Kidney Type of study: Etiology_studies Language: En Journal: J Ethnopharmacol Year: 2016 Type: Article Affiliation country: China

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