A place for precision medicine in bladder cancer: targeting the FGFRs.

di Martino, Erica; Tomlinson, Darren C; Williams, Sarah V; Knowles, Margaret A

di Martino, Erica; Tomlinson, Darren C; Williams, Sarah V; Knowles, Margaret A.

Affiliation

di Martino E; Section of Molecular Oncology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.
Tomlinson DC; Astbury Centre for Structural & Molecular Biology, School of Molecular & Cellular Biology, Astbury Building, University of Leeds, Leeds, LS2 9JT, UK.
Williams SV; Section of Molecular Oncology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.
Knowles MA; Section of Molecular Oncology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

Future Oncol ; 12(19): 2243-63, 2016 Oct.

Article in En | MEDLINE | ID: mdl-27381494

Subject(s)

Antineoplastic Agents/therapeutic use; ErbB Receptors/antagonists & inhibitors; Molecular Targeted Therapy; Precision Medicine; Urinary Bladder Neoplasms/drug therapy; Animals; Antineoplastic Agents/pharmacology; Biomarkers; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; ErbB Receptors/chemistry; ErbB Receptors/genetics; Gene Expression Regulation, Neoplastic; Humans; Ligands; Mutation; Neoplasm Staging; Patient Outcome Assessment; Patient Selection; Precision Medicine/methods; Prognosis; Receptor, Fibroblast Growth Factor, Type 1/genetics; Receptor, Fibroblast Growth Factor, Type 1/metabolism; Receptor, Fibroblast Growth Factor, Type 3/genetics; Receptor, Fibroblast Growth Factor, Type 3/metabolism; Signal Transduction/drug effects; Translocation, Genetic; Urinary Bladder Neoplasms/genetics; Urinary Bladder Neoplasms/mortality; Urinary Bladder Neoplasms/pathology

Key words

FGFR1; FGFR3; FGFRs; bladder; cancer; targeted therapy; urothelial

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Precision Medicine / Molecular Targeted Therapy / ErbB Receptors / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Future Oncol Year: 2016 Type: Article Affiliation country: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google