Application of a MABEL Approach for a T-Cell-Bispecific Monoclonal Antibody: CEA TCB.

Dudal, Sherri; Hinton, Heather; Giusti, Anna M; Bacac, Marina; Muller, Magali; Fauti, Tanja; Colombetti, Sara; Heckel, Tobias; Giroud, Nicolas; Klein, Christian; Umaña, Pablo; Benincosa, Lisa; Bachl, Juergen; Singer, Thomas; Bray-French, Katharine

Dudal, Sherri; Hinton, Heather; Giusti, Anna M; Bacac, Marina; Muller, Magali; Fauti, Tanja; Colombetti, Sara; Heckel, Tobias; Giroud, Nicolas; Klein, Christian; Umaña, Pablo; Benincosa, Lisa; Bachl, Juergen; Singer, Thomas; Bray-French, Katharine.

Affiliation

Dudal S; *Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Basel Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Glycart AG, Schlieren, Switzerland.

J Immunother ; 39(7): 279-89, 2016 09.

Article in En | MEDLINE | ID: mdl-27404941

Subject(s)

Antibodies, Bispecific/metabolism; CD3 Complex/immunology; Carcinoembryonic Antigen/immunology; Immunotherapy/methods; Neoplasms/therapy; Animals; Apoptosis; Cells, Cultured; Clinical Trials, Phase I as Topic; Cross Reactions; Drug Dosage Calculations; Drug Evaluation, Preclinical; Humans; Macaca fascicularis; Mice; Mice, Transgenic; Neoplasms/immunology; Rats; Structural Homology, Protein

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Full text: 1 Database: MEDLINE Main subject: Carcinoembryonic Antigen / CD3 Complex / Antibodies, Bispecific / Immunotherapy / Neoplasms Language: En Journal: J Immunother Year: 2016 Type: Article Affiliation country: Switzerland

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