Modified Panax ginseng Extract Inhibits uPAR-Mediated &#945;[Formula: see text]ß1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells.

Hwang, In-Hu; Kwon, Yong-Kyun; Cho, Chong-Kwan; Lee, Yeon-Weol; Sung, Jung-Suk; Joo, Jong-Cheon; Lee, Kyung-Bok; Yoo, Hwa-Seung; Jang, Ik-Soon

Modified Panax ginseng Extract Inhibits uPAR-Mediated α[Formula: see text]ß1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells.

Hwang, In-Hu; Kwon, Yong-Kyun; Cho, Chong-Kwan; Lee, Yeon-Weol; Sung, Jung-Suk; Joo, Jong-Cheon; Lee, Kyung-Bok; Yoo, Hwa-Seung; Jang, Ik-Soon.

Affiliation

Hwang IH; * Department of Physiology, Korea University College of Medicine, Seoul 136-705, Republic of Korea.
Kwon YK; East-West Cancer Center, Daejeon University, Daejeon 302-120, Republic of Korea.
Cho CK; East-West Cancer Center, Daejeon University, Daejeon 302-120, Republic of Korea.
Lee YW; East-West Cancer Center, Daejeon University, Daejeon 302-120, Republic of Korea.
Sung JS; Department of Life Science, Dongguk University, Goyang, Gyeonggi-do 10326, Republic of Korea.
Joo JC; § Department of Sasang Constitutional Medicine, Wonkwang University Oriental Medical Hospital, Jeonju 54887, Republic of Korea.
Lee KB; ¶ Division of Bioconvergence, Korea Basic Science Institute, Daejeon 305-333, Korea.
Yoo HS; East-West Cancer Center, Daejeon University, Daejeon 302-120, Republic of Korea.
Jang IS; ¶ Division of Bioconvergence, Korea Basic Science Institute, Daejeon 305-333, Korea.

Am J Chin Med ; 44(5): 1081-97, 2016.

Article in En | MEDLINE | ID: mdl-27430913

Subject(s)

Apoptosis/drug effects; Integrin alpha5beta1/metabolism; Lung Neoplasms/physiopathology; Panax/chemistry; Plant Extracts/pharmacology; Receptors, Urokinase Plasminogen Activator/metabolism; Signal Transduction/drug effects; Caspase 8/genetics; Caspase 8/metabolism; Caveolin 1/genetics; Caveolin 1/metabolism; Cell Line, Tumor; Humans; Integrin alpha5beta1/genetics; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Receptors, Urokinase Plasminogen Activator/genetics

Key words

Caveoline-1; Early Apoptosis; Integrin 1; MRGX; uPAR

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Full text: 1 Database: MEDLINE Main subject: Plant Extracts / Signal Transduction / Apoptosis / Integrin alpha5beta1 / Receptors, Urokinase Plasminogen Activator / Panax / Lung Neoplasms Type of study: Prognostic_studies Language: En Journal: Am J Chin Med Year: 2016 Type: Article

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