Effects of PUFAs in a Mouse Model of HSV-1 Chorioretinitis.
Ocul Immunol Inflamm
; 25(6): 844-854, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-27438625
ABSTRACT
PURPOSE:
To examine the effects of n-3 and n-6 polyunsaturated fatty acids (n-3 and n-6 PUFAs) in a murine model of herpetic chorioretinitis.METHODS:
BALB/c mice were fed on three high fat diets, which contained Menhaden oil (rich in n-3 PUFAs); Safflower oil (rich in n-6 PUFAs); or Corn oil (rich in saturated fatty acids) as control group, 14 days previously and until 12 days following anterior chamber (AC) HSV-1 inoculation.RESULTS:
Mice fed on Menhaden oil present an early development of contralateral chorioretinitis by day 6 post-AC HSV-1 inoculation and also significant increase of RNA HSV-1 expression compared with Safflower and Corn oil groups. Furthermore, mice fed on Menhaden oil showed a significant decrease secretion of TNF-α, IFN-γ, IL-2 and IL-10 in splenic cells and both retinas.CONCLUSION:
Our results showed that mice fed on Menhaden oil (n-3 PUFAs) presented an early development of contralateral chorioretinitis by day 6 post-AC HSV-1 inoculation and also a significant increase in RNA HSV-1 expression compared with animals fed on Safflower and Corn oils. This increase of HSV-1 could be associated with the higher development of chorioretinitis.
Full text:
1
Database:
MEDLINE
Main subject:
Eye Infections, Viral
/
Fatty Acids, Omega-3
/
Chorioretinitis
/
Herpesvirus 1, Human
/
Herpesviridae Infections
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Fatty Acids, Omega-6
/
Disease Models, Animal
Language:
En
Journal:
Ocul Immunol Inflamm
Year:
2017
Type:
Article
Affiliation country:
Argentina