Interaction of lafutidine in binding to human serum albumin in gastric ulcer therapy: STD-NMR, WaterLOGSY-NMR, NMR relaxation times, Tr-NOESY, molecule docking, and spectroscopic studies.

Yang, Hongqin; Huang, Yanmei; He, Jiawei; Li, Shanshan; Tang, Bin; Li, Hui

Yang, Hongqin; Huang, Yanmei; He, Jiawei; Li, Shanshan; Tang, Bin; Li, Hui.

Affiliation

Yang H; College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
Huang Y; College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
He J; College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
Li S; College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
Tang B; College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China.
Li H; College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China. Electronic address: lihuilab@sina.com.

Arch Biochem Biophys ; 606: 81-9, 2016 09 15.

Article in En | MEDLINE | ID: mdl-27457418

Subject(s)

Acetamides/chemistry; Piperidines/chemistry; Pyridines/chemistry; Serum Albumin/chemistry; Stomach Ulcer/blood; Stomach Ulcer/drug therapy; Binding Sites; Circular Dichroism; Humans; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Protein Binding; Protein Domains; Protein Structure, Secondary; Protons; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Warfarin/chemistry

Key words

Conformational changes; Human serum albumin; Lafutidine; Molecule docking; Relaxation experiments and tr-NOESY; STD and WaterLOGSY-NMR

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_mente_y_cuerpo / Relajacion Main subject: Piperidines / Pyridines / Stomach Ulcer / Serum Albumin / Acetamides Language: En Journal: Arch Biochem Biophys Year: 2016 Type: Article

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