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Synthesis and immunostimulatory activity of substituted TLR7 agonists.
Akinbobuyi, Babatope; Wang, Lei; Upchurch, Katherine C; Byrd, Matthew R; Chang, Charles A; Quintana, Jeremy M; Petersen, Rachel E; Seifert, Zacharie J; Boquin, José R; Oh, SangKon; Kane, Robert R.
Affiliation
  • Akinbobuyi B; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
  • Wang L; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
  • Upchurch KC; Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
  • Byrd MR; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
  • Chang CA; Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA.
  • Quintana JM; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
  • Petersen RE; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
  • Seifert ZJ; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
  • Boquin JR; Department of Chemistry, Augustana College, 639 38th Street, Rock Island, IL 61201, USA.
  • Oh S; Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
  • Kane RR; Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco,
Bioorg Med Chem Lett ; 26(17): 4246-9, 2016 09 01.
Article in En | MEDLINE | ID: mdl-27476423
Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.
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Full text: 1 Database: MEDLINE Main subject: Adenine / Adjuvants, Immunologic / Toll-Like Receptor 7 Language: En Journal: Bioorg Med Chem Lett Year: 2016 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Adenine / Adjuvants, Immunologic / Toll-Like Receptor 7 Language: En Journal: Bioorg Med Chem Lett Year: 2016 Type: Article Affiliation country: United States