Your browser doesn't support javascript.
loading
Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs.
Liu, Xiao; Xia, Xueliang; Sun, Chenghai; Lin, Cai; Zhou, Yiqian; Hussain, Muzammal; Tang, Fei; Liu, Lu; Li, Xue; Zhang, Jiancun.
Affiliation
  • Liu X; a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
  • Xia X; a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
  • Sun C; a Institute of Pharmaceutical Research , South China Normal University , Guangzhou , Guangdong , PR China.
  • Lin C; b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
  • Zhou Y; b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
  • Hussain M; b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
  • Tang F; c University of Chinese Academy of Sciences , Beijing , PR China.
  • Liu L; b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
  • Li X; c University of Chinese Academy of Sciences , Beijing , PR China.
  • Zhang J; b Guangzhou Institutes of Biomedicine and Heath , Chinese Academy of Sciences , Guangzhou , PR China.
Nucleosides Nucleotides Nucleic Acids ; 35(9): 479-94, 2016 Sep.
Article in En | MEDLINE | ID: mdl-27556785
ABSTRACT
The preparation of 2'-deoxy-2'-siprodifluorocyclopropany-lnucleoside analogs has been achieved from α-d-glucose in several steps. The key step in the synthesis was the introduction of the difluorocyclopropane through a difluorocarbene type reaction at the 2'-position. Then, a series of novel 2'-deoxy-2'-spirodifluorocyclopropanyl nucleoside analogs were synthesized using the Vorbrüggen method. All the synthesized nucleosides were characterized and subsequently evaluated against hepatitis C and influenza A virus strains in vitro.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Spiro Compounds / Nucleosides Language: En Journal: Nucleosides Nucleotides Nucleic Acids Year: 2016 Type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Spiro Compounds / Nucleosides Language: En Journal: Nucleosides Nucleotides Nucleic Acids Year: 2016 Type: Article