Droplet digital PCR to investigate quasi-species at codons 119 and 275 of the A(H1N1)pdm09 neuraminidase during zanamivir and oseltamivir therapies.

Abed, Yacine; Carbonneau, Julie; L'Huillier, Arnaud G; Kaiser, Laurent; Boivin, Guy

Abed, Yacine; Carbonneau, Julie; L'Huillier, Arnaud G; Kaiser, Laurent; Boivin, Guy.

Affiliation

Abed Y; Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, QC, Canada.
Carbonneau J; Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, QC, Canada.
L'Huillier AG; Laboratory of Virology, University of Geneva Hospitals, Geneva, Switzerland.
Kaiser L; Laboratory of Virology, University of Geneva Hospitals, Geneva, Switzerland.
Boivin G; Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, QC, Canada.

J Med Virol ; 89(4): 737-741, 2017 04.

Article in En | MEDLINE | ID: mdl-27602879

Subject(s)

Antiviral Agents/therapeutic use; Genetic Variation; Influenza A Virus, H1N1 Subtype/enzymology; Influenza, Human/drug therapy; Influenza, Human/virology; Neuraminidase/genetics; Polymerase Chain Reaction/methods; Codon; Drug Resistance, Viral; Genotyping Techniques/methods; Humans; Male; Microbial Sensitivity Tests/methods; Middle Aged; Mutation, Missense; Oseltamivir/therapeutic use; Sensitivity and Specificity; Zanamivir/therapeutic use

Key words

A(H1N1)pdm09; E119D; H275Y; dd-PCR; oseltamivir; zanamivir

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Antiviral Agents / Genetic Variation / Polymerase Chain Reaction / Influenza, Human / Influenza A Virus, H1N1 Subtype / Neuraminidase Type of study: Diagnostic_studies / Evaluation_studies Language: En Journal: J Med Virol Year: 2017 Type: Article Affiliation country: Canada

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