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Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.
Ma, Guang-Hui; Ye, Yan; Zhang, Dan; Xu, Xin; Si, Pei; Peng, Jian-Long; Xiao, Yong-Long; Cao, Rui-Yuan; Yin, Yu-Ling; Chen, Jing; Zhao, Lin-Xiang; Zhou, Yu; Zhong, Wu; Liu, Hong; Luo, Xiao-Min; Chen, Li-Li; Shen, Xu.
Affiliation
  • Ma GH; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Rd, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, 100
  • Ye Y; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Rd, Beijing 100191, China; Univ
  • Zhang D; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, 103 Culture Rd, Shenyang 1
  • Xu X; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Si P; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; College of Life and Environmental Sciences, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China.
  • Peng JL; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Xiao YL; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Cao RY; Beijing Institute of Pharmacology and Toxicology, 27 Taiping Rd., Beijing 100850, China.
  • Yin YL; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Chen J; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Zhao LX; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, 103 Culture Rd, Shenyang 110016, China.
  • Zhou Y; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: zhouyu@simm.ac.cn.
  • Zhong W; Beijing Institute of Pharmacology and Toxicology, 27 Taiping Rd., Beijing 100850, China.
  • Liu H; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Luo XM; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Rd, Beijing 100191, China. Elec
  • Chen LL; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: lilichen@simm.ac.cn.
  • Shen X; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Eur J Med Chem ; 124: 981-991, 2016 Nov 29.
Article in En | MEDLINE | ID: mdl-27776325
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Oxazoles / Pyridines / Viral Proteins / Enterovirus A, Human Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Eur J Med Chem Year: 2016 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Oxazoles / Pyridines / Viral Proteins / Enterovirus A, Human Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Eur J Med Chem Year: 2016 Type: Article