In vitro chondrocyte toxicity following long-term, high-dose exposure to Gd-DTPA and a novel cartilage-targeted MR contrast agent.

Midura, Sharon; Schneider, Erika; Rosen, Gerald M; Winalski, Carl S; Midura, Ronald J

Midura, Sharon; Schneider, Erika; Rosen, Gerald M; Winalski, Carl S; Midura, Ronald J.

Affiliation

Midura S; Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Schneider E; Imaging Institute, A21, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Rosen GM; NitroSci Pharmaceuticals, New Berlin, WI, 53151, USA.
Winalski CS; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.
Midura RJ; NitroSci Pharmaceuticals, New Berlin, WI, 53151, USA.

Skeletal Radiol ; 46(1): 23-33, 2017 Jan.

Article in En | MEDLINE | ID: mdl-27815598

Subject(s)

Cartilage, Articular/drug effects; Chondrocytes/drug effects; Contrast Media/toxicity; Gadolinium DTPA/toxicity; Animals; Cartilage, Articular/metabolism; Cartilage, Articular/pathology; Cell Proliferation; Chondrocytes/metabolism; Chondrocytes/pathology; Contrast Media/administration & dosage; Dendrimers/administration & dosage; Dendrimers/toxicity; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gadolinium DTPA/administration & dosage; Magnetic Resonance Imaging; Rats; Staurosporine; Tumor Cells, Cultured/drug effects

Key words

Biochemistry; Cartilage; Contrast agent; Cytotoxicity; Dendrimer; Gadolinium; Gd-DTPA; MRI

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Database: MEDLINE Main subject: Cartilage, Articular / Contrast Media / Chondrocytes / Gadolinium DTPA Type of study: Prognostic_studies Language: En Journal: Skeletal Radiol Year: 2017 Type: Article Affiliation country: United States

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