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Vertebrate embryos as tools for anti-angiogenic drug screening and function.
Beedie, Shaunna L; Diamond, Alexandra J; Fraga, Lucas Rosa; Figg, William D; Vargesson, Neil.
Affiliation
  • Beedie SL; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, US
  • Diamond AJ; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
  • Fraga LR; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
  • Figg WD; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.
  • Vargesson N; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. Electronic address: n.vargesson@abdn.ac.uk.
Reprod Toxicol ; 70: 49-59, 2017 06.
Article in En | MEDLINE | ID: mdl-27888069
The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
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Full text: 1 Database: MEDLINE Main subject: Neovascularization, Physiologic / Angiogenesis Inhibitors / Drug Evaluation, Preclinical / Embryo, Mammalian / Embryo, Nonmammalian Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Reprod Toxicol Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Neovascularization, Physiologic / Angiogenesis Inhibitors / Drug Evaluation, Preclinical / Embryo, Mammalian / Embryo, Nonmammalian Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Reprod Toxicol Year: 2017 Type: Article