Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.

Liu, Yan; Zhi, Dejuan; Li, Menghui; Liu, Dongling; Wang, Xin; Wu, Zhengrong; Zhang, Zhanxin; Fei, Dongqing; Li, Yang; Zhu, Hongmei; Xie, Qingjian; Yang, Hui; Li, Hongyu

Liu, Yan; Zhi, Dejuan; Li, Menghui; Liu, Dongling; Wang, Xin; Wu, Zhengrong; Zhang, Zhanxin; Fei, Dongqing; Li, Yang; Zhu, Hongmei; Xie, Qingjian; Yang, Hui; Li, Hongyu.

Affiliation

Liu Y; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Zhi D; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Li M; Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P.R. China.
Liu D; Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P.R. China.
Wang X; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Wu Z; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Zhang Z; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Fei D; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Li Y; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Zhu H; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.
Xie Q; Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, P.R. China.
Yang H; Institute of Biology, Academy of Sciences, Lanzhou 730000, Gansu province, P.R. China.
Li H; Gansu high throughput screening and creation center for health products, School of Pharmacy, Lanzhou University, Donggang West Road No. 199, Lanzhou 730020, P.R. China.

Sci Rep ; 6: 38934, 2016 12 16.

Article in En | MEDLINE | ID: mdl-27982058

Subject(s)

Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Cyclophilins/metabolism; Drugs, Chinese Herbal/pharmacology; MAP Kinase Signaling System/drug effects; Mitochondrial Membrane Transport Proteins/metabolism; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins/genetics; Peptidyl-Prolyl Isomerase F; Cyclophilins/genetics; Drug Combinations; MAP Kinase Signaling System/genetics; Mitochondrial Membrane Transport Proteins/genetics; Mitochondrial Permeability Transition Pore; Mutation; Neoplasms/drug therapy; Neoplasms/genetics; Neoplasms/metabolism; Oncogene Protein p21(ras)/genetics; Oncogene Protein p21(ras)/metabolism

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Drugs, Chinese Herbal / Caenorhabditis elegans / MAP Kinase Signaling System / Cyclophilins / Caenorhabditis elegans Proteins / Mitochondrial Membrane Transport Proteins Language: En Journal: Sci Rep Year: 2016 Type: Article

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