Using the "target constituent removal combined with bioactivity assay" strategy to investigate the optimum arecoline content in charred areca nut.

Peng, Wei; Liu, Yu-Jie; Hu, Mei-Bian; Yan, Dan; Gao, Yong-Xiang; Wu, Chun-Jie

Peng, Wei; Liu, Yu-Jie; Hu, Mei-Bian; Yan, Dan; Gao, Yong-Xiang; Wu, Chun-Jie.

Affiliation

Peng W; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.
Liu YJ; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.
Hu MB; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.
Yan D; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.
Gao YX; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.
Wu CJ; College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.

Sci Rep ; 7: 40278, 2017 01 05.

Article in En | MEDLINE | ID: mdl-28054652

Subject(s)

Areca/toxicity; Arecoline/isolation & purification; Arecoline/toxicity; Animals; Apoptosis; Areca/chemistry; Cell Line; Gastric Emptying/drug effects; Gastrointestinal Tract/drug effects; Humans; Mice; Motilin/metabolism; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Plant Extracts/toxicity; Rats, Sprague-Dawley; Toxicity Tests/methods; Vasoactive Intestinal Peptide/metabolism

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