&#945;-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis.

Takeda, Tomoki; Matsuo, Yuki; Nishida, Kyoko; Fujiki, Akihisa; Hattori, Yukiko; Koga, Takayuki; Ishii, Yuji; Yamada, Hideyuki

α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis.

Takeda, Tomoki; Matsuo, Yuki; Nishida, Kyoko; Fujiki, Akihisa; Hattori, Yukiko; Koga, Takayuki; Ishii, Yuji; Yamada, Hideyuki.

Affiliation

Takeda T; Graduate School of Pharmaceutical Sciences, Kyushu University.

J Toxicol Sci ; 42(1): 13-23, 2017.

Article in En | MEDLINE | ID: mdl-28070105

Subject(s)

AMP-Activated Protein Kinases/metabolism; Brain/drug effects; Polychlorinated Dibenzodioxins/toxicity; Receptors, LHRH/genetics; Thioctic Acid/pharmacology; Adenosine Triphosphate/metabolism; Animals; Brain/metabolism; Female; Fetus/drug effects; Fetus/metabolism; Gonadotropin-Releasing Hormone/genetics; Kidney/drug effects; Kidney/metabolism; Liver/drug effects; Liver/metabolism; Luteinizing Hormone/blood; Luteinizing Hormone/genetics; Male; Myocardium/metabolism; Phosphoproteins/genetics; Phosphoproteins/metabolism; Pregnancy; RNA, Messenger/metabolism; Rats, Wistar; Testis/drug effects; Testis/metabolism

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Full text: 1 Database: MEDLINE Main subject: Brain / Thioctic Acid / Receptors, LHRH / AMP-Activated Protein Kinases / Polychlorinated Dibenzodioxins Language: En Journal: J Toxicol Sci Year: 2017 Type: Article

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