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Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats.
Zhao, Yi; Liu, Yan; Lan, Xi-Ming; Xu, Guo-Liang; Sun, You-Zhi; Li, Fei; Liu, Hong-Ning.
Affiliation
  • Zhao Y; Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
  • Liu Y; Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
  • Lan XM; Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
  • Xu GL; Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
  • Sun YZ; School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
  • Li F; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences, Kunming 650201, China.
  • Liu HN; Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Nanchang 330004, China.
Evid Based Complement Alternat Med ; 2016: 1213090, 2016.
Article in En | MEDLINE | ID: mdl-28119756
ABSTRACT
Dendrobium officinale (Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects of Dendrobium officinale. However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to evaluate the effect of Dendrobium officinale on cancer, and its pharmacological mechanism was explored. Dendrobium officinale extracts (4.8 and 2.4 g/kg) were orally administered to the rats of the gastric carcinogenesis model. Compared with the cancer model group, the high dose of Dendrobium officinale extracts significantly inhibited the rate of carcinogenesis. Further analysis revealed that Dendrobium officinale extracts could regulate the DNA damage, oxidative stress, and cytokines related with carcinogenesis and induce cell apoptosis in order to prevent gastric cancer.
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Full text: 1 Database: MEDLINE Language: En Journal: Evid Based Complement Alternat Med Year: 2016 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Language: En Journal: Evid Based Complement Alternat Med Year: 2016 Type: Article Affiliation country: China