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Aristolochic acid derivatives from the rhizome of Arisolochia championii.
Wang, Xin; Shi, Guo-Ru; Liu, Yan-Fei; Li, Li; Chen, Ruo-Yun; Yu, De-Quan.
Affiliation
  • Wang X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Shi GR; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Liu YF; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Li L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Chen RY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Yu DQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: dqyu@imm.ac.cn.
Fitoterapia ; 118: 63-68, 2017 Apr.
Article in En | MEDLINE | ID: mdl-28137630
ABSTRACT
Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5-14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC50 values of 0.50, 7.37, 2.66, and 0.75µM, respectively.
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Full text: 1 Database: MEDLINE Main subject: Aristolochia / Rhizome / Aristolochic Acids Language: En Journal: Fitoterapia Year: 2017 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Aristolochia / Rhizome / Aristolochic Acids Language: En Journal: Fitoterapia Year: 2017 Type: Article Affiliation country: China