Toxicological evaluation of 5-methoxy-2-aminoindane (MEAI): Binge mitigating agent in development.

Shimshoni, Jakob A; Winkler, Ilan; Edery, Nir; Golan, Ezekiel; van Wettum, René; Nutt, David

Shimshoni, Jakob A; Winkler, Ilan; Edery, Nir; Golan, Ezekiel; van Wettum, René; Nutt, David.

Affiliation

Shimshoni JA; Kimron Veterinary Institute, Department of Toxicology, Bet Dagan, Israel. Electronic address: jakobshimshoni@gmail.com.
Winkler I; Pharmaseed Ltd, Ness Ziona, Israel.
Edery N; Kimron Veterinary Institute, Department of Pathology, Bet Dagan, Israel.
Golan E; BSC BV Company, Veemarkt 61, Amsterdam, The Netherland.
van Wettum R; BSC BV Company, Veemarkt 61, Amsterdam, The Netherland.
Nutt D; Imperial College London, Neuropsychopharmacology Unit, London, UK.

Toxicol Appl Pharmacol ; 319: 59-68, 2017 03 15.

Article in En | MEDLINE | ID: mdl-28167221

Subject(s)

Binge Drinking; Body Weight/drug effects; Drug Discovery/methods; Indans/toxicity; Animals; Binge Drinking/prevention & control; Binge Drinking/psychology; Body Weight/physiology; Brain/drug effects; Brain/physiology; Drug Evaluation, Preclinical/methods; Female; Hepatocytes/drug effects; Hepatocytes/physiology; Humans; Indans/chemistry; Indans/therapeutic use; Male; Rats; Rats, Sprague-Dawley; Toxicity Tests, Subacute/methods

Key words

5-Methoxy-2-aminoindane (MEAI); Acute toxicity; Cytotoxicity; Ethanol; Subacute toxicity

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Full text: 1 Database: MEDLINE Main subject: Body Weight / Drug Discovery / Binge Drinking / Indans Language: En Journal: Toxicol Appl Pharmacol Year: 2017 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Body Weight / Drug Discovery / Binge Drinking / Indans Language: En Journal: Toxicol Appl Pharmacol Year: 2017 Type: Article