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Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.
Misu, Hirofumi; Takayama, Hiroaki; Saito, Yoshiro; Mita, Yuichiro; Kikuchi, Akihiro; Ishii, Kiyo-Aki; Chikamoto, Keita; Kanamori, Takehiro; Tajima, Natsumi; Lan, Fei; Takeshita, Yumie; Honda, Masao; Tanaka, Mutsumi; Kato, Seiji; Matsuyama, Naoto; Yoshioka, Yuya; Iwayama, Kaito; Tokuyama, Kumpei; Akazawa, Nobuhiko; Maeda, Seiji; Takekoshi, Kazuhiro; Matsugo, Seiichi; Noguchi, Noriko; Kaneko, Shuichi; Takamura, Toshinari.
Affiliation
  • Misu H; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Takayama H; PRESTO, Japan Science and Technology Agency, Kawaguchi, Japan.
  • Saito Y; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Mita Y; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Kikuchi A; Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.
  • Ishii KA; Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.
  • Chikamoto K; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Kanamori T; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Tajima N; Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Lan F; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Takeshita Y; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Honda M; Division of Natural System, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan.
  • Tanaka M; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Kato S; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Matsuyama N; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Yoshioka Y; Department of Endocrinology and Metabolism, Chengdu First People's Hospital, Chengdu, China.
  • Iwayama K; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Tokuyama K; Department of System Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
  • Akazawa N; Diagnostic R&D, R&D Headquarters, Alfresa Pharma Corporation, Ibaraki, Japan.
  • Maeda S; Diagnostic R&D, R&D Headquarters, Alfresa Pharma Corporation, Ibaraki, Japan.
  • Takekoshi K; Diagnostic R&D, R&D Headquarters, Alfresa Pharma Corporation, Ibaraki, Japan.
  • Matsugo S; Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.
  • Noguchi N; Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Kaneko S; Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Takamura T; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Nat Med ; 23(4): 508-516, 2017 Apr.
Article in En | MEDLINE | ID: mdl-28263310
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Full text: 1 Database: MEDLINE Main subject: Physical Conditioning, Animal / Physical Endurance / Receptors, LDL / Reactive Oxygen Species / Muscle, Skeletal / Tumor Suppressor Proteins / Selenoprotein P / AMP-Activated Protein Kinases / Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Type of study: Prognostic_studies Language: En Journal: Nat Med Year: 2017 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Physical Conditioning, Animal / Physical Endurance / Receptors, LDL / Reactive Oxygen Species / Muscle, Skeletal / Tumor Suppressor Proteins / Selenoprotein P / AMP-Activated Protein Kinases / Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Type of study: Prognostic_studies Language: En Journal: Nat Med Year: 2017 Type: Article Affiliation country: Japan