Inhibitory effects of 3&#945;-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-&#945;, IL-1ß, and the high mobility group box 1 release in macrophages.

Liu, Xiang-Qian; Zou, Qin-Peng; Huang, Jian-Jun; Yook, Chang-Soo; Whang, Wan-Kyunn; Lee, Hyeong-Kyu; Kwon, Ok-Kyoung

Inhibitory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-α, IL-1ß, and the high mobility group box 1 release in macrophages.

Liu, Xiang-Qian; Zou, Qin-Peng; Huang, Jian-Jun; Yook, Chang-Soo; Whang, Wan-Kyunn; Lee, Hyeong-Kyu; Kwon, Ok-Kyoung.

Affiliation

Liu XQ; a School of Pharmacy, Hunan University of Chinese Medicine , Changsha , China.
Zou QP; b School of Chemistry and Chemical Engineering, Central South University , Changsha , China.
Huang JJ; b School of Chemistry and Chemical Engineering, Central South University , Changsha , China.
Yook CS; c Changsha Broad-Ocean Bio-science and Technique Co.,Ltd. , Changsha , China.
Whang WK; d Department of Clinical Biochemistry , Xiangya Medical College, Central South University , Changsha , China.
Lee HK; e College of Pharmacy, KyungHee University , Seoul , Korea.
Kwon OK; f College of Pharmacy, Chung-Ang University , Seoul , Korea.

Biosci Biotechnol Biochem ; 81(7): 1305-1313, 2017 Jul.

Article in En | MEDLINE | ID: mdl-28345393

Subject(s)

Anti-Inflammatory Agents/pharmacology; Drugs, Chinese Herbal/chemistry; HMGB1 Protein/antagonists & inhibitors; Interleukin-1beta/antagonists & inhibitors; Macrophages/drug effects; Triterpenes/pharmacology; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Animals; Anti-Inflammatory Agents/isolation & purification; Cell Line; Dose-Response Relationship, Drug; Eleutherococcus; Gene Expression; HMGB1 Protein/genetics; HMGB1 Protein/metabolism; Inflammation; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Lipopolysaccharides/antagonists & inhibitors; Lipopolysaccharides/pharmacology; Macrophages/cytology; Macrophages/metabolism; Mice; NF-KappaB Inhibitor alpha/antagonists & inhibitors; NF-KappaB Inhibitor alpha/genetics; NF-KappaB Inhibitor alpha/metabolism; Nitric Oxide/antagonists & inhibitors; Nitric Oxide/biosynthesis; Phosphorylation/drug effects; Triterpenes/isolation & purification; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism

Key words

3α-hydroxy-lup-20(29)-en-23,28-dioic acid; HMGB1; IL-1ß; TNF-α; anti-inflammatory

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Triterpenes / Drugs, Chinese Herbal / Tumor Necrosis Factor-alpha / HMGB1 Protein / Interleukin-1beta / Macrophages / Anti-Inflammatory Agents Language: En Journal: Biosci Biotechnol Biochem Year: 2017 Type: Article Affiliation country: China

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