Investigating the ion dependence of the first unfolding step of GTPase-Associating Center ribosomal RNA.

Hayatshahi, Hamed S; Bergonzo, Christina; Cheatham, Thomas E

Hayatshahi, Hamed S; Bergonzo, Christina; Cheatham, Thomas E.

Affiliation

Hayatshahi HS; a Department of Medicinal Chemistry , College of Pharmacy, The University of Utah , 2000 East 30 South Skaggs 307, Salt Lake City , Utah 84112-5820 , USA.
Bergonzo C; a Department of Medicinal Chemistry , College of Pharmacy, The University of Utah , 2000 East 30 South Skaggs 307, Salt Lake City , Utah 84112-5820 , USA.
Cheatham TE; a Department of Medicinal Chemistry , College of Pharmacy, The University of Utah , 2000 East 30 South Skaggs 307, Salt Lake City , Utah 84112-5820 , USA.

J Biomol Struct Dyn ; 36(1): 243-253, 2018 01.

Article in En | MEDLINE | ID: mdl-28406059

Subject(s)

Cations/chemistry; GTP Phosphohydrolases/chemistry; Nucleic Acid Conformation; RNA, Ribosomal/chemistry; Cations/metabolism; GTP Phosphohydrolases/metabolism; Magnesium/chemistry; Magnesium/metabolism; Molecular Dynamics Simulation; Protein Binding; RNA, Ribosomal/metabolism

Key words

AmberZ; GTPase-Associating Center; chelated magnesium; molecular dynamics; umbrella sampling; unfolding pathway

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Full text: 1 Database: MEDLINE Main subject: RNA, Ribosomal / Cations / GTP Phosphohydrolases / Nucleic Acid Conformation Type of study: Risk_factors_studies Language: En Journal: J Biomol Struct Dyn Year: 2018 Type: Article Affiliation country: United States

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