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Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.
Fliegert, Ralf; Watt, Joanna M; Schöbel, Anja; Rozewitz, Monika D; Moreau, Christelle; Kirchberger, Tanja; Thomas, Mark P; Sick, Wiebke; Araujo, Andrea C; Harneit, Angelika; Potter, Barry V L; Guse, Andreas H.
Affiliation
  • Fliegert R; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Watt JM; Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
  • Schöbel A; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.
  • Rozewitz MD; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Moreau C; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Kirchberger T; Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
  • Thomas MP; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Sick W; Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
  • Araujo AC; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Harneit A; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Potter BVL; The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  • Guse AH; Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.
Biochem J ; 474(13): 2159-2175, 2017 06 16.
Article in En | MEDLINE | ID: mdl-28515263
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Full text: 1 Database: MEDLINE Main subject: Arginine / Tyrosine / Adenosine Diphosphate Ribose / TRPM Cation Channels Type of study: Prognostic_studies Language: En Journal: Biochem J Year: 2017 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Arginine / Tyrosine / Adenosine Diphosphate Ribose / TRPM Cation Channels Type of study: Prognostic_studies Language: En Journal: Biochem J Year: 2017 Type: Article Affiliation country: Germany