Cytotoxic pterosins from Pteris multifida roots against HCT116 human colon cancer cells.
Bioorg Med Chem Lett
; 27(14): 3144-3147, 2017 07 15.
Article
in En
| MEDLINE
| ID: mdl-28532669
ABSTRACT
Two new pterosin glycosides, (2S,3S)-pterosin C 3-O-ß-d-(4'-(E)-caffeoyl)-glucopyranoside (1) and (2S,3S)-pterosin C 3-O-ß-d-(6'-(E)-p-coumaroyl)-glucopyranoside (2), were isolated from Pteris multifida (Pteridaceae) roots along with ten known pterosin compounds (3-12). The chemical structures of the isolated compounds were elucidated by extensive analysis of the 1D, 2D NMR, HRESIMS, and CD spectroscopic data. The cytotoxicities of 1-12 against HCT116 human colorectal cancer cell line were evaluated. Among the isolates, compound 1 showed moderate antiproliferative activity in HCT116 cells with an IC50 value of 8.0±1.7µM. Additionally, 1 induced the upregulation of the caspase-9 and procaspase-9 levels in Western blots and increased the annexin V/propidium iodide (PI)-positive cell population in flow cytometry.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Pteris
/
Indans
Language:
En
Journal:
Bioorg Med Chem Lett
Year:
2017
Type:
Article