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Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning, Changwen; Liang, Min; Liu, Shuang; Wang, Guan; Edwards, Holly; Xia, Yang; Polin, Lisa; Dyson, Gregory; Taub, Jeffrey W; Mohammad, Ramzi M; Azmi, Asfar S; Zhao, Lijing; Ge, Yubin.
Affiliation
  • Ning C; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China.
  • Liang M; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China.
  • Liu S; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China.
  • Wang G; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, P.R. China.
  • Edwards H; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Xia Y; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
  • Polin L; Department of Pathology, The Second Hospital of Jilin University, Changchun, P.R. China.
  • Dyson G; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Taub JW; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
  • Mohammad RM; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
  • Azmi AS; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
  • Zhao L; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
  • Ge Y; Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA.
Oncotarget ; 8(27): 44295-44311, 2017 Jul 04.
Article in En | MEDLINE | ID: mdl-28574828
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Purines / Morpholines / Extracellular Signal-Regulated MAP Kinases / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Phosphoinositide-3 Kinase Inhibitors / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Oncotarget Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pancreatic Neoplasms / Purines / Morpholines / Extracellular Signal-Regulated MAP Kinases / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases / Phosphoinositide-3 Kinase Inhibitors / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Oncotarget Year: 2017 Type: Article