A nationwide study of the incidence rate of herb-induced liver injury in Korea.
Arch Toxicol
; 91(12): 4009-4015, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-28634823
ABSTRACT
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7. All these participants were women and developed the hepatocellular type of HILI. One HILI participant met the criteria for Hy's law; however, none of six cases presented clinical symptoms related to liver injury. This is the first nationwide prospective study that estimated the extent of the incidence of HILI [total 0.60%, 95% confidence interval (CI) 0.12-1.08; women 0.95%, 95% CI 0.19-1.68] and described its features in hospitalized participants.
Key words
Full text:
1
Database:
MEDLINE
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Drugs, Chinese Herbal
/
Chemical and Drug Induced Liver Injury
/
Liver
Type of study:
Clinical_trials
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Arch Toxicol
Year:
2017
Type:
Article
Affiliation country:
South Korea