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Cytotoxic effects of gastrodin extracted from the rhizome of Gastrodia elata Blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation.
Liang, Wei-Zhe; Jan, Chung-Ren; Hsu, Shu-Shong.
Affiliation
  • Liang WZ; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan, ROC.
  • Jan CR; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan, ROC.
  • Hsu SS; Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan, ROC; Department of Surgery, National Defense Medical Center, Taipei 11490, Taiwan, ROC. Electronic address: haussoo67@gmail.com.
Food Chem Toxicol ; 107(Pt A): 280-292, 2017 Sep.
Article in En | MEDLINE | ID: mdl-28689919
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Full text: 1 Database: MEDLINE Main subject: Benzyl Alcohols / Plant Extracts / Tumor Suppressor Protein p53 / Apoptosis / Glioblastoma / Oxidative Stress / Gastrodia / Cell Cycle Checkpoints / Glucosides Type of study: Risk_factors_studies Language: En Journal: Food Chem Toxicol Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Benzyl Alcohols / Plant Extracts / Tumor Suppressor Protein p53 / Apoptosis / Glioblastoma / Oxidative Stress / Gastrodia / Cell Cycle Checkpoints / Glucosides Type of study: Risk_factors_studies Language: En Journal: Food Chem Toxicol Year: 2017 Type: Article