9,19-Cycloartenol glycoside G3 from Cimicifuga simplex regulates immune responses by modulating Th17/Treg ratio.

Su, Yang; Wu, Lun; Mu, Guangrui; Wang, Qiuhong; Yang, Bingyou; Cheng, Genhong; Kuang, Haixue

Su, Yang; Wu, Lun; Mu, Guangrui; Wang, Qiuhong; Yang, Bingyou; Cheng, Genhong; Kuang, Haixue.

Affiliation

Su Y; Key Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, PR China; Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: suyanggo@163.com.
Wu L; Key Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, PR China. Electronic address: wulun2012@163.com.
Mu G; Graduate School of Heilongjiang, University of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, PR China.
Wang Q; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China. Electronic address: 4865238@qq.com.
Yang B; Key Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, PR China. Electronic address: 624333699@qq.com.
Cheng G; Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: suyanggo@126.com.
Kuang H; Key Laboratory of Chinese Material Medica, Department of Pharmacology, Heilongjiang University of Chinese Medicine, Harbin, PR China. Electronic address: suyanggo@yeah.net.

Bioorg Med Chem ; 25(17): 4917-4923, 2017 09 01.

Article in En | MEDLINE | ID: mdl-28780985

Subject(s)

Cimicifuga/chemistry; Glycosides/chemistry; Glycosides/pharmacology; T-Lymphocytes, Regulatory/cytology; Th17 Cells/cytology; Animals; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/metabolism; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Cimicifuga/metabolism; Cytokines/pharmacology; Disease Models, Animal; Female; Forkhead Transcription Factors/metabolism; Glycosides/therapeutic use; Interleukin-17/metabolism; Mice; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism; Plant Roots/chemistry; Plant Roots/metabolism; Signal Transduction/drug effects; Skin Diseases/drug therapy; Skin Diseases/pathology; Spleen/cytology; Spleen/drug effects; Spleen/metabolism; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/metabolism; Th17 Cells/drug effects; Th17 Cells/metabolism

Key words

9,19-Cycloartenol glycosides; Cimicifuga simplex; IL-17(+)RORÎ³t(+)/IL-10(+)FoxP(3+) ratio; JAK/STAT pathways

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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Cimicifuga / Th17 Cells / Glycosides Type of study: Prognostic_studies Language: En Journal: Bioorg Med Chem Year: 2017 Type: Article

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