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Effects of resveratrol on rat neurosteroid synthetic enzymes.
Wang, Yiluan; Sun, Jianliang; Chen, Ling; Zhou, Songyi; Lin, Han; Wang, Yiyan; Lin, Nengming; Ge, Ren-Shan.
Affiliation
  • Wang Y; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
  • Sun J; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
  • Chen L; Translational Medicine Research Center, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Nanjing Medical University, No. 261 Huansha Road, Hangzhou, Zhejiang 310006, China.
  • Zhou S; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
  • Lin H; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
  • Wang Y; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
  • Lin N; Translational Medicine Research Center, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Nanjing Medical University, No. 261 Huansha Road, Hangzhou, Zhejiang 310006, China. Electronic address: lnm1013@163.com.
  • Ge RS; Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address: renshan_ge@wmu.edu.cn.
Fitoterapia ; 122: 61-66, 2017 Oct.
Article in En | MEDLINE | ID: mdl-28823883
Resveratrol, a common polyphenol, has extensive pharmacological activities. Resveratrol inhibits some steroid biosynthetic enzymes, indicating that it may block neurosteroid synthesis. The objective of the present study is to investigate the inhibition of resveratrol on neurosteroidogenic enzymes rat 5α-reductase 1 (SRD5A1), 3α-hydroxysteroid dehydrogenase (AKR1C9), and retinol dehydrogenase 2 (RDH2). The IC50 values of resveratrol on SRD5A1, AKR1C9, and RDH2 were >100µM, 0.436±0.070µM, and 4.889±0.062µM, respectively. Resveratrol competitively inhibited rat AKR1C9 and RDH2 against steroid substrates. Docking showed that resveratrol bound to the steroid binding pocket of AKR1C9. It exerted a mixed mode on these AKR1C9 and RDH2 against cofactors. In conclusion, resveratrol potently inhibited rat AKR1C9 and RDH2 to regulate local neurosteroid levels.
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Full text: 1 Database: MEDLINE Main subject: Oxidoreductases / Stilbenes / Neurotransmitter Agents / Alcohol Oxidoreductases / Membrane Proteins Language: En Journal: Fitoterapia Year: 2017 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Oxidoreductases / Stilbenes / Neurotransmitter Agents / Alcohol Oxidoreductases / Membrane Proteins Language: En Journal: Fitoterapia Year: 2017 Type: Article Affiliation country: China