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Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification.
Qu, Guangbo; Liu, Wei; Zhao, Yuetao; Gao, Jie; Xia, Tian; Shi, Jianbo; Hu, Ligang; Zhou, Wenhua; Gao, Jiejun; Wang, Huaiyu; Luo, Qian; Zhou, Qunfang; Liu, Sijin; Yu, Xue-Feng; Jiang, Guibin.
Affiliation
  • Qu G; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
  • Liu W; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
  • Zhao Y; Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing, 100176, P. R. China.
  • Gao J; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
  • Xia T; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
  • Shi J; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
  • Hu L; Division of Nanomedicine, Department of Medicine, University of California Los Angeles, California, 90095, USA.
  • Zhou W; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
  • Gao J; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
  • Wang H; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
  • Luo Q; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
  • Zhou Q; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
  • Liu S; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
  • Yu XF; Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
  • Jiang G; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P. R. China.
Angew Chem Int Ed Engl ; 56(46): 14488-14493, 2017 11 13.
Article in En | MEDLINE | ID: mdl-28892587
ABSTRACT
Black phosphorus nanosheets (BPs) show great potential for various applications including biomedicine, thus their potential side effects and corresponding improvement strategy deserve investigation. Here, in vitro and in vivo biological effects of BPs with and without titanium sulfonate ligand (TiL4 ) modification are investigated. Compared to bare BPs, BPs with TiL4 modification (TiL4 @BPs) can efficiently escape from macrophages uptake, and reduce cytotoxicity and proinflammation. The corresponding mechanisms are also discussed. These findings may not only guide the applications of BPs, but also propose an efficient strategy to further improve the biocompatibility of BPs.
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Full text: 1 Database: MEDLINE Main subject: Phosphorus / Biocompatible Materials / Nanostructures Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Phosphorus / Biocompatible Materials / Nanostructures Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Type: Article