Pharmacokinetic interaction of green tea beverage containing cyclodextrins and high concentration catechins with P-glycoprotein substrates in LLC-GA5-COL150 cells in vitro and in the small intestine of rats in vivo.

Oda, Keisuke; Murakami, Teruo

Oda, Keisuke; Murakami, Teruo.

Affiliation

Oda K; Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima, Japan.
Murakami T; Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima, Japan.

J Pharm Pharmacol ; 69(12): 1736-1744, 2017 Dec.

Article in En | MEDLINE | ID: mdl-28980319

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Cyclodextrins/chemistry; Food-Drug Interactions; Tea/chemistry; Animals; Biological Transport; Catechin/chemistry; Cell Line; Digoxin/administration & dosage; Digoxin/chemistry; Digoxin/pharmacokinetics; Intestinal Absorption; Intestine, Small/metabolism; Male; Quinidine/administration & dosage; Quinidine/chemistry; Quinidine/pharmacokinetics; Rats; Rats, Sprague-Dawley; Rhodamine 123/administration & dosage; Rhodamine 123/chemistry; Rhodamine 123/pharmacokinetics; Solubility; Swine

Key words

P-glycoprotein; catechin; cyclodextrin; green tea beverage; solubilizing activity

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Full text: 1 Database: MEDLINE Main subject: Tea / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Food-Drug Interactions / Cyclodextrins Language: En Journal: J Pharm Pharmacol Year: 2017 Type: Article Affiliation country: Japan

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