Virtual screening and biological evaluation of biofilm inhibitors on dual targets in quorum sensing system.

Xu, Yinqiu; Tong, Xupeng; Sun, Pinghua; Bi, Leming; Lin, Kejiang

Xu, Yinqiu; Tong, Xupeng; Sun, Pinghua; Bi, Leming; Lin, Kejiang.

Affiliation

Xu Y; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Tong X; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Sun P; College of Pharmacy, Jinan University, Guangzhou 510632, China.
Bi L; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Lin K; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Future Med Chem ; 9(17): 1983-1994, 2017 11.

Article in En | MEDLINE | ID: mdl-29076756

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacterial Proteins/agonists; Bacterial Proteins/antagonists & inhibitors; Biofilms/drug effects; Pseudomonas aeruginosa/drug effects; Quorum Sensing/drug effects; Repressor Proteins/agonists; Trans-Activators/antagonists & inhibitors; Anti-Bacterial Agents/chemistry; Drug Evaluation, Preclinical; Microbial Sensitivity Tests; Models, Molecular; Structure-Activity Relationship

Key words

LasR antagonists; QscR agonists; biofilm inhibitor; quorum sensing; virtual screening

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Full text: 1 Database: MEDLINE Main subject: Pseudomonas aeruginosa / Repressor Proteins / Bacterial Proteins / Trans-Activators / Biofilms / Quorum Sensing / Anti-Bacterial Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Future Med Chem Year: 2017 Type: Article Affiliation country: China

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