Encapsulation Mechanism of Oxyresveratrol by ß-Cyclodextrin and Hydroxypropyl-ß-Cyclodextrin and Computational Analysis.
Molecules
; 22(11)2017 Oct 31.
Article
in En
| MEDLINE
| ID: mdl-29088059
ABSTRACT
In this study, the encapsulation mechanism of oxyresveratrol and ß-cyclodextrin (ß-CD) and hydroxypropyl-ß-cyclodextrin (HP-ß-CD) was studied. As this research shows, oxyresveratrol and two cyclodextrins (CDs) were able to form inclusion complexes in a 11 stoichiometry. However, the interaction with HP-ß-CD was more efficient, showing up as higher encapsulation constant (KF) (35,864.72 ± 3415.89 M-1). The KF values exhibited a strong dependence on temperature and pH, which decreased as they increased. From the thermodynamic parameters (ΔH°, ΔS°, and ΔG°) of the oxyresveratrol loaded ß-CD (oxyresveratrol-ß-CD) and HP-ß-CD (oxyresveratrol-HP-ß-CD), it could be seen that the complexation process was spontaneous and exothermic, and the main driving forces between oxyrsveratrol and CDs were hydrogen bonding and van der waals force. Besides, molecular docking combined with ¹H-NMR were used to explain the most possible mode of interactions between oxyresveratrol and CDs.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Stilbenes
/
Plant Extracts
/
Beta-Cyclodextrins
/
2-Hydroxypropyl-beta-cyclodextrin
Language:
En
Journal:
Molecules
Year:
2017
Type:
Article
Affiliation country:
China