Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Uddin, Golam Mezbah; Youngson, Neil A; Doyle, Bronte M; Sinclair, David A; Morris, Margaret J

Uddin, Golam Mezbah; Youngson, Neil A; Doyle, Bronte M; Sinclair, David A; Morris, Margaret J.

Affiliation

Uddin GM; Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, NSW-2032, Australia.
Youngson NA; Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, NSW-2032, Australia.
Doyle BM; Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, NSW-2032, Australia.
Sinclair DA; Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, NSW-2032, Australia.
Morris MJ; Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA-02115, USA.

Sci Rep ; 7(1): 15063, 2017 11 08.

Article in En | MEDLINE | ID: mdl-29118320

Subject(s)

Dietary Supplements; Nicotinamide Mononucleotide/pharmacology; Obesity/prevention & control; Physical Conditioning, Animal/physiology; Animals; DNA, Mitochondrial/genetics; DNA, Mitochondrial/metabolism; Diet, High-Fat; Female; Gene Expression/drug effects; Male; Mice, Inbred C57BL; Mitochondria/drug effects; Mitochondria/genetics; Mitochondria/metabolism; Nicotinamide Mononucleotide/administration & dosage; Obesity/genetics; Obesity/physiopathology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism; Pregnancy; Triglycerides/metabolism; Weaning

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Full text: 1 Database: MEDLINE Main subject: Physical Conditioning, Animal / Dietary Supplements / Nicotinamide Mononucleotide / Obesity Language: En Journal: Sci Rep Year: 2017 Type: Article Affiliation country: Australia

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