Low-folate stress reprograms cancer stem cell-like potentials and bioenergetics metabolism through activation of mTOR signaling pathway to promote in vitro invasion and in vivo tumorigenicity of lung cancers.

Chen, Wan-Jing; Huang, Rwei-Fen S

Chen, Wan-Jing; Huang, Rwei-Fen S.

Affiliation

Chen WJ; Ph.D. program in Nutrition and Food Sciences, Fu Jen Catholic University, Taiwan, ROC.
Huang RS; Ph.D. program in Nutrition and Food Sciences, Fu Jen Catholic University, Taiwan, ROC; Department of Nutritional Science, Fu Jen Catholic University, Taiwan, ROC. Electronic address: 034825@mail.fju.edu.tw.

J Nutr Biochem ; 53: 28-38, 2018 03.

Article in En | MEDLINE | ID: mdl-29190547

Subject(s)

Folic Acid/pharmacology; Lung Neoplasms/pathology; Neoplastic Stem Cells/drug effects; TOR Serine-Threonine Kinases/metabolism; Animals; Cell Line, Tumor; Cell Movement/drug effects; Energy Metabolism/drug effects; Fibroblasts/cytology; Fibroblasts/drug effects; Fibroblasts/metabolism; Folic Acid/administration & dosage; Humans; Lung/cytology; Lung Neoplasms/metabolism; Male; Mice, Inbred C57BL; Neoplastic Stem Cells/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Tumor Microenvironment/drug effects; Xenograft Model Antitumor Assays

Key words

Low folate; Lung cancer stem cell; Metabolic signaling; Tumorigenesis; bioenergetics

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_energeticas / Bioenergetica Main subject: Neoplastic Stem Cells / TOR Serine-Threonine Kinases / Folic Acid / Lung Neoplasms Language: En Journal: J Nutr Biochem Year: 2018 Type: Article

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