Low-protein diet supplemented with ketoacids delays the progression of diabetic nephropathy by inhibiting oxidative stress in the KKAy mice model.

Liu, Dongmei; Wu, Ming; Li, Lin; Gao, Xiang; Yang, Bo; Mei, Shuqin; Fu, Lili; Mei, Changlin

Liu, Dongmei; Wu, Ming; Li, Lin; Gao, Xiang; Yang, Bo; Mei, Shuqin; Fu, Lili; Mei, Changlin.

Affiliation

Liu D; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Wu M; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Li L; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Gao X; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Yang B; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Mei S; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Fu L; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.
Mei C; Department of Nephrology,Shanghai Changzheng Hospital,Kidney Institute,Second Military Medical University,Shanghai,200003, People's Republic of China.

Br J Nutr ; 119(1): 22-29, 2018 01.

Article in En | MEDLINE | ID: mdl-29208058

Subject(s)

Diabetic Nephropathies/diet therapy; Diet, Protein-Restricted; Keto Acids/chemistry; Oxidative Stress; Renal Insufficiency, Chronic/diet therapy; Albuminuria/therapy; Animals; Diabetes Mellitus, Experimental/diet therapy; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Type 2/diet therapy; Diabetes Mellitus, Type 2/metabolism; Diabetic Nephropathies/metabolism; Dietary Supplements; Disease Models, Animal; Glomerular Basement Membrane/metabolism; Kidney/metabolism; Male; Mice; Mice, Inbred C57BL; Organ Size; Renal Insufficiency, Chronic/metabolism

Key words

CKD chronic kidney disease; DN diabetic nephropathy; GBM glomerular basement membrane; KA ketoacids; LPD low-protein diet; LPD+KA LPD supplemented with KA; MDA malondialdehyde; NPD normal protein diet; NT nitrotyrosin; SOD superoxide dismutase; Diabetic nephropathy; Ketoacids; Low-protein diets; Oxidative stress

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Full text: 1 Database: MEDLINE Main subject: Oxidative Stress / Diet, Protein-Restricted / Diabetic Nephropathies / Renal Insufficiency, Chronic / Keto Acids Language: En Journal: Br J Nutr Year: 2018 Type: Article

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