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Advances in ovarian cancer therapy.
Cortez, Alexander J; Tudrej, Patrycja; Kujawa, Katarzyna A; Lisowska, Katarzyna M.
Affiliation
  • Cortez AJ; Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, 44-100, Poland.
  • Tudrej P; Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, 44-100, Poland.
  • Kujawa KA; Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, 44-100, Poland.
  • Lisowska KM; Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, 44-100, Poland. katarzyna.lisowska@io.gliwice.pl.
Cancer Chemother Pharmacol ; 81(1): 17-38, 2018 01.
Article in En | MEDLINE | ID: mdl-29249039
Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of complete remissions; however, the recurrence rate is also high. For most patients, the disease eventually becomes a continuum of symptom-free periods and recurrence episodes. Different targeted treatment approaches and biological drugs, currently under development, bring the promise of turning ovarian cancer into a manageable chronic disease. In this review, we discuss the current standard in the therapy for ovarian cancer, major recent studies on the new variants of conventional therapies, and new therapeutic approaches, recently approved and/or in clinical trials. The latter include anti-angiogenic therapies, polyADP-ribose polymerase (PARP) inhibitors, inhibitors of growth factor signaling, or folate receptor inhibitors, as well as several immunotherapeutic approaches. We also discuss cost-effectiveness of some novel therapies and the issue of better selection of patients for personalized treatment.
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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms Type of study: Prognostic_studies Language: En Journal: Cancer Chemother Pharmacol Year: 2018 Type: Article Affiliation country: Poland

Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms Type of study: Prognostic_studies Language: En Journal: Cancer Chemother Pharmacol Year: 2018 Type: Article Affiliation country: Poland