Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA­155­5p inhibition.

Wang, Jun; Li, Dan; Hou, Jincai; Lei, Hongtao

Protective effects of geniposide and ginsenoside Rg1 combination treatment on rats following cerebral ischemia are mediated via microglial microRNA1555p inhibition.

Wang, Jun; Li, Dan; Hou, Jincai; Lei, Hongtao.

Affiliation

Wang J; Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.
Li D; Jingjinji United Innovation Pharmaceutical Research Company, Beijing 100083, P.R. China.
Hou J; Jingjinji United Innovation Pharmaceutical Research Company, Beijing 100083, P.R. China.
Lei H; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.

Mol Med Rep ; 17(2): 3186-3193, 2018 Feb.

Article in En | MEDLINE | ID: mdl-29257264

Subject(s)

Brain Ischemia/drug therapy; Ginsenosides/therapeutic use; Iridoids/therapeutic use; MicroRNAs/metabolism; Neuroprotective Agents/therapeutic use; Animals; Brain/metabolism; Brain/pathology; Brain Ischemia/etiology; Brain Ischemia/pathology; CD11b Antigen/metabolism; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Ginsenosides/pharmacology; Glucose/deficiency; Infarction, Middle Cerebral Artery/complications; Iridoids/pharmacology; Male; MicroRNAs/antagonists & inhibitors; Microglia/cytology; Microglia/drug effects; Microglia/metabolism; Neuroprotective Agents/pharmacology; Panax notoginseng/chemistry; Panax notoginseng/metabolism; Rats; Rats, Sprague-Dawley

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Brain Ischemia / Neuroprotective Agents / Iridoids / Ginsenosides / MicroRNAs Type of study: Etiology_studies Language: En Journal: Mol Med Rep Year: 2018 Type: Article

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