Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism.

Yang, Rui; Jia, Qiang; Liu, Xiao-Fen; Ma, Shan-Feng

Yang, Rui; Jia, Qiang; Liu, Xiao-Fen; Ma, Shan-Feng.

Affiliation

Yang R; Department of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Jia Q; Department of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Liu XF; Department of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Ma SF; Department of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.

Mol Med Rep ; 17(2): 2929-2936, 2018 Feb.

Article in En | MEDLINE | ID: mdl-29257312

Subject(s)

Cardiomyopathies/drug therapy; Diabetes Mellitus, Type 1/complications; Genistein/therapeutic use; Myocardium/pathology; Phytoestrogens/therapeutic use; Animals; Cardiomyopathies/blood; Cardiomyopathies/pathology; Collagen Type I/analysis; Diabetes Mellitus, Experimental/blood; Diabetes Mellitus, Experimental/complications; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Type 1/blood; Diabetes Mellitus, Type 1/pathology; Fibrosis; Heart/drug effects; Hemodynamics/drug effects; Male; Rats; Rats, Sprague-Dawley; Smad3 Protein/analysis; Smad4 Protein/analysis; Transforming Growth Factor beta1/analysis

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Full text: 1 Database: MEDLINE Main subject: Genistein / Phytoestrogens / Diabetes Mellitus, Type 1 / Cardiomyopathies / Myocardium Language: En Journal: Mol Med Rep Year: 2018 Type: Article

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