Bacterial Nanocellulose Loaded with Bromelain: Assessment of Antimicrobial, Antioxidant and Physical-Chemical Properties.
Sci Rep
; 7(1): 18031, 2017 12 21.
Article
in En
| MEDLINE
| ID: mdl-29269741
ABSTRACT
Bacterial nanocellulose (BNC) has desirable properties for wound healing such as high purity, good shape retention, and high water binding capacity. Bromelain is a protease found in pineapple tissues and has been applied in several fields, it has anti-inflammatory and anticancer properties, promotes cell apoptosis, amongst others. In this work, a BNC based device for the controlled release of bromelain was developed. BNC were submersed in sterilized bromelain solution and incubated at 25 °C under 100 rpm for 24 h. Physical-chemical properties, protein concentration, antioxidant and antimicrobial activities were measured. Results demonstrate that BNC could improve bromelain antimicrobial activity 9 times. Those findings allow concluding that bromelain is a promising molecule to be incorporated into BNC's. The BNC's characteristics seem to represent a new promising delivery system of the loaded biomolecule, and protected from external actions.
Full text:
1
Database:
MEDLINE
Main subject:
Wound Healing
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Bromelains
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Cellulose
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Anti-Infective Agents
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Anti-Bacterial Agents
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Antioxidants
Language:
En
Journal:
Sci Rep
Year:
2017
Type:
Article
Affiliation country:
Brazil