CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats.

Xu, Ye; Zhang, Yi-Fan; Chen, Xiao-Yan; Zhong, Da-Fang

Xu, Ye; Zhang, Yi-Fan; Chen, Xiao-Yan; Zhong, Da-Fang.

Affiliation

Xu Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Zhang YF; University of Chinese Academy of Sciences, Beijing, 100049, China.
Chen XY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Zhong DF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Acta Pharmacol Sin ; 39(8): 1386-1392, 2018 Aug.

Article in En | MEDLINE | ID: mdl-29283173

Subject(s)

Cytochrome P-450 CYP3A Inducers/therapeutic use; Cytochrome P-450 CYP3A Inhibitors/therapeutic use; Dexamethasone/therapeutic use; Diterpenes/pharmacokinetics; Phenanthrenes/pharmacokinetics; Ritonavir/therapeutic use; Administration, Oral; Animals; Cytochrome P-450 CYP3A/metabolism; Diterpenes/administration & dosage; Drug Interactions; Epoxy Compounds/administration & dosage; Epoxy Compounds/pharmacokinetics; Humans; Male; Phenanthrenes/administration & dosage; Rats, Sprague-Dawley

Key words

(5R)-5-hydroxytriptolide; CYP3A4; dexamethasone; immunosuppressant; pharmacokinetics; ritonavir; traditional Chinese medicine; triptolide

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Phenanthrenes / Dexamethasone / Ritonavir / Diterpenes / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors Language: En Journal: Acta Pharmacol Sin Year: 2018 Type: Article Affiliation country: China

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