SIRT1 inhibitory compounds from the roots of Codonopsis pilosula.
J Asian Nat Prod Res
; 21(1): 25-32, 2019 Jan.
Article
in En
| MEDLINE
| ID: mdl-29319339
ABSTRACT
Three new compounds, pilosulinene A (1), pilosulinols A (2), and B (3), along with seven known compounds, were isolated from the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan Province. The structures of new compounds were established by spectroscopic methods. In particular, the presence of an aromatic ring in the structure of 1 makes it intriguing. The inhibitory activity of compounds against SIRT1 was evaluated. The results showed that 8 could inhibit Sirt1 in a dose-dependent manner.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Plant Extracts
/
Codonopsis
/
Sirtuin 1
Language:
En
Journal:
J Asian Nat Prod Res
Year:
2019
Type:
Article
Affiliation country:
China