Spirulina ameliorates methotrexate hepatotoxicity via antioxidant, immune stimulation, and proinflammatory cytokines and apoptotic proteins modulation.

Khafaga, Asmaa F; El-Sayed, Yasser S

Khafaga, Asmaa F; El-Sayed, Yasser S.

Affiliation

Khafaga AF; Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Edfina 22758, Egypt. Electronic address: asmaa.khafaga@alexu.edu.eg.
El-Sayed YS; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt. Electronic address: elsayed-ys@vetmed.dmu.edu.eg.

Life Sci ; 196: 9-17, 2018 Mar 01.

Article in En | MEDLINE | ID: mdl-29339102

Subject(s)

Adjuvants, Immunologic/pharmacology; Antimetabolites/toxicity; Antioxidants/pharmacology; Apoptosis Regulatory Proteins/antagonists & inhibitors; Chemical and Drug Induced Liver Injury/prevention & control; Cytokines/antagonists & inhibitors; Methotrexate/antagonists & inhibitors; Methotrexate/toxicity; Plant Extracts/pharmacology; Spirulina/chemistry; Animals; Leukocyte Count; Lipid Peroxidation/drug effects; Male; Necrosis; Rats; Rats, Wistar; Spleen/pathology

Key words

Apoptosis; Cytokines; Immunoglobulins; Lipid peroxidation; Liver; Methotrexate; Spirulina platensis

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Full text: 1 Database: MEDLINE Main subject: Plant Extracts / Adjuvants, Immunologic / Methotrexate / Cytokines / Apoptosis Regulatory Proteins / Spirulina / Chemical and Drug Induced Liver Injury / Antimetabolites / Antioxidants Language: En Journal: Life Sci Year: 2018 Type: Article

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