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Recurrent intussusception among infants less than 2 years of age in Vietnam.
Trang, Nguyen V; Burnett, Eleanor; Ly, Le H; Anh, Nguyen P; Hung, Pham H; Linh, Hoang M; Trang, Nguyen C T; Canh, Tran M; Minh, Vu T; Tate, Jacqueline E; Yen, Catherine; Anh, Dang D; Parashar, Umesh D.
Affiliation
  • Trang NV; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.
  • Burnett E; Centers for Disease Control and Prevention, USA.
  • Ly LH; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.
  • Anh NP; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.
  • Hung PH; Pediatric Center, Hue Central Hospital, Hue, Viet Nam.
  • Linh HM; Pediatric Center, Hue Central Hospital, Hue, Viet Nam.
  • Trang NCT; Hai Phong Children Hospital, Hai Phong, Viet Nam.
  • Canh TM; Hai Phong Children Hospital, Hai Phong, Viet Nam.
  • Minh VT; Hai Phong Children Hospital, Hai Phong, Viet Nam.
  • Tate JE; Centers for Disease Control and Prevention, USA.
  • Yen C; Centers for Disease Control and Prevention, USA.
  • Anh DD; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.
  • Parashar UD; Centers for Disease Control and Prevention, USA. Electronic address: uap2@cdc.gov.
Vaccine ; 36(51): 7901-7905, 2018 12 14.
Article in En | MEDLINE | ID: mdl-29478753
In some settings, rotavirus vaccines have been associated with a low-level risk of intussusception, the most common cause of bowel obstruction in infants. As Vietnam prepares to introduce rotavirus vaccine into the national immunization program, we sought to better characterize the epidemiology of recurrent intussusception. We enrolled children <2 years of age who were hospitalized for intussusception retrospectively from January 2013 through December 2014 and prospectively from January 2015 through December 2016 at 2 hospitals in Vietnam. We enrolled 2477 children. Nearly all children were successfully treated by enema with low surgery rate (1%). We found 10% of children (n = 254) experienced at least once recurrence (range: 1-6) and 57% of first recurrences happened within the first 12 weeks after treatment of the first episode. The median age at first intussusception was 13 months for children without a recurrent episode and 10 months for children with a recurrence. The symptoms of the recurrent cases were milder with less vomiting (67%), bloody stool (7%) and fever (10%) compared to the initial cases (p < 0.01). We found the rate of recurrences following enema reduction of intussusception to be similar to that reported from other countries. Due to the high rate of intussusception and recurrent episodes in Vietnam, a better understanding of the cause of recurrent intussusception will be critical in assessing intussusception cases after rotavirus introduction.
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Full text: 1 Database: MEDLINE Main subject: Hospitalization / Intussusception Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Country/Region as subject: Asia Language: En Journal: Vaccine Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Hospitalization / Intussusception Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Country/Region as subject: Asia Language: En Journal: Vaccine Year: 2018 Type: Article