Systemic administration of scAAV9-IGF1 extends survival in SOD1<sup>G93A</sup> ALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway.

Wang, Wan; Wen, Di; Duan, Weisong; Yin, Juntao; Cui, Can; Wang, Ying; Li, Zhongyao; Liu, Yakun; Li, Chunyan

Systemic administration of scAAV9-IGF1 extends survival in SOD1^G93A ALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway.

Wang, Wan; Wen, Di; Duan, Weisong; Yin, Juntao; Cui, Can; Wang, Ying; Li, Zhongyao; Liu, Yakun; Li, Chunyan.

Affiliation

Wang W; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China; Department of Neurology, Affiliated Xing Tai People Hospital of Hebei Medical University, Xingtai, Hebei, 054000, People's Republic of China.
Wen D; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China.
Duan W; Neurological Laboratory of Hebei Province, Shijiazhuang, Hebei, 050000, People's Republic of China.
Yin J; Department of Neurology, Xing Tai Third Hospital, Xingtai, Hebei, 054000, People's Republic of China.
Cui C; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China.
Wang Y; Department of Neurology, The Central Hospital of Zibo, Zibo, Shandong, 255000, People's Republic of China.
Li Z; Neurological Laboratory of Hebei Province, Shijiazhuang, Hebei, 050000, People's Republic of China.
Liu Y; Neurological Laboratory of Hebei Province, Shijiazhuang, Hebei, 050000, People's Republic of China.
Li C; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China; Institute of Cardiocerebrovascular Disease, West Heping Road 215, Shijiazhuang, Hebei, 050000, People's Republic of China; Neurological Laboratory of Hebei Province, Shi

Brain Res Bull ; 139: 203-210, 2018 05.

Article in En | MEDLINE | ID: mdl-29499331

Subject(s)

Amyotrophic Lateral Sclerosis/therapy; Apoptosis/physiology; Insulin-Like Growth Factor I/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Amyotrophic Lateral Sclerosis/genetics; Amyotrophic Lateral Sclerosis/mortality; Amyotrophic Lateral Sclerosis/pathology; Animals; Calcium-Binding Proteins/metabolism; Dependovirus/physiology; Disease Models, Animal; Female; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Insulin-Like Growth Factor I/genetics; JNK Mitogen-Activated Protein Kinases/genetics; Mice; Mice, Transgenic; Microfilament Proteins/metabolism; Muscle, Skeletal/metabolism; Muscle, Skeletal/pathology; Mutation/genetics; Phosphopyruvate Hydratase/metabolism; Phosphorylation; Spinal Cord/metabolism; Statistics, Nonparametric; Superoxide Dismutase/genetics; p38 Mitogen-Activated Protein Kinases/genetics

Key words

Amyotrophic lateral sclerosis; Apoptosis; Insulin-like growth factor 1; Transgenic SOD1-G93A mice; c-Jun-N-terminal kinase; p38 mitogen-activated protein kinase

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Full text: 1 Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Apoptosis / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Language: En Journal: Brain Res Bull Year: 2018 Type: Article

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