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Synergic highly effective photothermal-chemotherapy with platinum prodrug linked melanin-like nanoparticles.
Zhang, Chengwei; Zhao, Xiaozhi; Guo, Hongqian.
Affiliation
  • Zhang C; a Department of Urology , Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University , Nanjing , P. R. China.
  • Zhao X; a Department of Urology , Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University , Nanjing , P. R. China.
  • Guo H; a Department of Urology , Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University , Nanjing , P. R. China.
Artif Cells Nanomed Biotechnol ; 46(sup2): 356-363, 2018.
Article in En | MEDLINE | ID: mdl-29607699
ABSTRACT
Cisplatin is widely used in cancer treatment, but the application is limited due to toxicities and its acquired resistance. In this study, we delivered cisplatin to prostate cancer cells by linking the platinum prodrug Pt(IV) to melanin-like nanoparticles (MeNPs), a promising photothermal therapeutic agent with excellent biocompatibility. As expected, the Pt(IV)-MeNPs exhibited brilliant synergic photothermal-chemotherapy upon near-infrared reflection exposure. Compared with free cisplatin, Pt(IV)-MeNPs displayed highly effective antitumour activity both in vitro and in vivo.
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Full text: 1 Database: MEDLINE Main subject: Phototherapy / Drug Carriers / Prodrugs / Cisplatin / Nanoparticles / Melanins / Antineoplastic Agents Language: En Journal: Artif Cells Nanomed Biotechnol Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Phototherapy / Drug Carriers / Prodrugs / Cisplatin / Nanoparticles / Melanins / Antineoplastic Agents Language: En Journal: Artif Cells Nanomed Biotechnol Year: 2018 Type: Article